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<P class=MsoNormal style="MARGIN: 6pt 0cm 0pt; TEXT-ALIGN: center; mso-layout-grid-align: none" align=center><B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt"></SPAN></B> </P>
<P class=MsoNormal style="MARGIN: 6pt 0cm 0pt; TEXT-ALIGN: center; mso-layout-grid-align: none" align=center><B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt">Riunione intermedia del Progetto di Interesse Nazionale (PRIN) 2007<o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 6pt 0cm 0pt; TEXT-ALIGN: center; mso-layout-grid-align: none" align=center><I><SPAN style="FONT-SIZE: 16pt; COLOR: blue">Metodi statistici per l'apprendimento nella ricerca clinica<o:p></o:p></SPAN></I></P>
<P class=MsoNormal style="MARGIN: 6pt 0cm 0pt; TEXT-ALIGN: center; mso-layout-grid-align: none" align=center><I><SPAN lang=EN-GB style="FONT-SIZE: 14pt; COLOR: blue; mso-bidi-font-size: 16.0pt; mso-ansi-language: EN-GB">(Statistical methods for learning in clinical research)</SPAN></I><SPAN lang=EN-GB style="FONT-SIZE: 14pt; COLOR: blue; mso-bidi-font-size: 16.0pt; mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 6pt 0cm 0pt; TEXT-ALIGN: center" align=center><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-bidi-font-weight: bold">Si terrą al<B> </B></SPAN><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 10.0pt; mso-bidi-font-weight: bold; mso-fareast-font-family: Batang">Dipartimento di Scienze Statistiche dell’Universitą di Bologna </SPAN><B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt"><o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 6pt 0cm 0pt; TEXT-ALIGN: center" align=center><B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt">VENERDI 19 giugno 2009</SPAN></B><B><SPAN style="FONT-SIZE: 14pt; FONT-FAMILY: Arial; mso-bidi-font-size: 12.0pt"><o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 6pt 0cm 0pt; TEXT-ALIGN: center" align=center><B><SPAN style="FONT-SIZE: 14pt; FONT-FAMILY: Arial; mso-bidi-font-size: 12.0pt"> <o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 12pt 0cm 6pt; TEXT-ALIGN: center" align=center><B style="mso-bidi-font-weight: normal"><SPAN style="FONT-SIZE: 14pt; COLOR: black; mso-bidi-font-size: 16.0pt">Programma</SPAN></B></P>
<P class=MsoNormal style="MARGIN: 12pt 0cm 6pt; TEXT-ALIGN: center" align=center><B style="mso-bidi-font-weight: normal"><SPAN style="FONT-SIZE: 14pt; COLOR: black; mso-bidi-font-size: 16.0pt"></SPAN></B><SPAN style="FONT-SIZE: 14pt">10.45<SPAN style="mso-tab-count: 1"> </SPAN></SPAN><SPAN style="FONT-WEIGHT: normal; FONT-SIZE: 14pt">Apertura dei lavori da parte del Responsabile Nazionale del Progetto</SPAN><SPAN style="FONT-SIZE: 14pt"><o:p></o:p></SPAN></P>
<H2 style="MARGIN: 12pt 0cm 0pt 144pt; TEXT-INDENT: -117pt; LINE-HEIGHT: normal"><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-ansi-language: EN-GB">11.00 – 11.45</SPAN><SPAN lang=EN-GB style="FONT-WEIGHT: normal; FONT-SIZE: 14pt; mso-ansi-language: EN-GB"><SPAN style="mso-tab-count: 1"> </SPAN></SPAN><SPAN lang=EN-GB style="FONT-SIZE: 11pt; FONT-FAMILY: Verdana; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">Randomization and its impact on inference <SPAN style="mso-tab-count: 1"> </SPAN></SPAN><SPAN lang=EN-GB style="FONT-WEIGHT: normal; FONT-SIZE: 11pt; FONT-FAMILY: Verdana; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">(</SPAN><SPAN lang=EN-GB style="FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-ansi-language: EN-GB">William F. Rosenberger, </SPAN><SPAN lang=EN-GB style="FONT-WEIGHT: normal; FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-ansi-language: EN-GB">George Mason University</SPAN><FONT size=3><SPAN lang=EN-GB style="FONT-WEIGHT: normal; FONT-FAMILY: Arial; mso-ansi-language: EN-GB">)</SPAN><I style="mso-bidi-font-style: normal"><SPAN lang=EN-GB style="FONT-WEIGHT: normal; FONT-SIZE: 14pt; mso-ansi-language: EN-GB"><o:p></o:p></SPAN></I></FONT></H2>
<P class=MsoNormal style="MARGIN: 12pt 0cm 0pt 141.5pt; TEXT-INDENT: -114.55pt"><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">11.45 – 12.00</SPAN></B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; COLOR: black; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB"><SPAN style="mso-tab-count: 1"> </SPAN></SPAN><B><SPAN lang=EN-GB style="FONT-SIZE: 11pt; FONT-FAMILY: Verdana; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">Estimation following Adaptively Randomised Clinical Trials</SPAN></B><SPAN lang=EN-GB style="FONT-SIZE: 10pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-GB"> <SPAN style="mso-tab-count: 1"> </SPAN>(</SPAN><B style="mso-bidi-font-weight: normal"><SPAN lang=EN-GB style="FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-ansi-language: EN-GB">Steven Coad, </SPAN></B><SPAN lang=EN-GB style="FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-ansi-language: EN-GB">Queen Mary College, London)</SPAN><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB"> <o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 12pt 0cm 0pt 141.5pt; TEXT-INDENT: -114.55pt"><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">12.30 </SPAN></B><B style="mso-bidi-font-weight: normal"><SPAN lang=EN-GB style="FONT-SIZE: 14pt; COLOR: black; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">–13.00</SPAN></B><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB"><SPAN style="mso-tab-count: 1"> </SPAN></SPAN></B><B><SPAN lang=EN-GB style="FONT-SIZE: 11pt; FONT-FAMILY: Verdana; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">Improved modelling of interactions in multiple-agent dose-finding studies</SPAN></B><SPAN lang=EN-GB style="FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-ansi-language: EN-GB"> <SPAN style="mso-tab-count: 1"> </SPAN><SPAN style="mso-spacerun: yes"> </SPAN>(<B style="mso-bidi-font-weight: normal">Mauro Gasparini, </B>Politecnico di Torino)</SPAN><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold"> <o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 12pt 0cm 0pt 141.5pt; TEXT-INDENT: -114.55pt"><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB"><SPAN style="mso-tab-count: 4"> </SPAN>Discussione</SPAN></B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P>
<P class=MsoBodyTextIndent3 style="MARGIN: 12pt 0cm 6pt 144.05pt; TEXT-INDENT: -117.1pt; LINE-HEIGHT: 150%; TEXT-ALIGN: center" align=center><B><SPAN style="COLOR: maroon; FONT-FAMILY: Batang">13.15 – 14.30<SPAN style="mso-spacerun: yes"> </SPAN>Pranzo</SPAN></B><SPAN style="COLOR: maroon; FONT-FAMILY: Batang"><o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 6pt 0cm 0pt 126pt; TEXT-INDENT: -99pt; TEXT-ALIGN: justify; tab-stops: right 0cm"><B style="mso-bidi-font-weight: normal"><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 10.0pt; mso-fareast-font-family: Batang">14.30 – 15.00 </SPAN></B><B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt"><SPAN style="mso-tab-count: 1"></SPAN></SPAN></B><SPAN style="FONT-SIZE: 14pt"><SPAN style="mso-spacerun: yes"> </SPAN><SPAN style="mso-tab-count: 1"> </SPAN><I style="mso-bidi-font-style: normal">Titolo da Definire</I> (</SPAN><B style="mso-bidi-font-weight: normal"><SPAN style="FONT-SIZE: 10pt; FONT-FAMILY: Arial">Marco Bonetti, </SPAN></B><SPAN style="FONT-SIZE: 10pt; FONT-FAMILY: Arial">UniBocconi Milano</SPAN><SPAN style="FONT-SIZE: 14pt">)</SPAN><SPAN style="FONT-SIZE: 14pt; mso-fareast-font-family: 'Arial Unicode MS'"><o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 12pt 0cm 0pt 141.5pt; TEXT-INDENT: -114.55pt; TEXT-ALIGN: justify"><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">15.00 – 15.30<SPAN style="mso-tab-count: 1"> </SPAN></SPAN></B><B><SPAN lang=EN-GB style="FONT-SIZE: 11pt; FONT-FAMILY: Verdana; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">Adapting by calibration the sample size of a<BR>phase III trial on the basis of phase II data <SPAN style="mso-tab-count: 1"></SPAN></SPAN></B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold">(</SPAN><B style="mso-bidi-font-weight: normal"><SPAN lang=EN-GB style="FONT-SIZE: 10pt; COLOR: black; FONT-FAMILY: Arial; mso-ansi-language: EN-GB">Daniele De Martini, </SPAN></B><SPAN lang=EN-GB style="FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-ansi-language: EN-GB">Universitą del Piemonte Orientale</SPAN><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold">)</SPAN><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-ansi-language: EN-GB"><o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 12pt 0cm 0pt 141.6pt; TEXT-INDENT: -114.6pt"><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-ansi-language: EN-GB">15.30<SPAN style="mso-spacerun: yes"> </SPAN></SPAN></B><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">– 16.00<SPAN style="mso-tab-count: 1"> </SPAN></SPAN></B><B><SPAN lang=EN-GB style="FONT-SIZE: 11pt; FONT-FAMILY: Verdana; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB">Ethics and Inference in Clinical Trials: Admissible Allocations and Covariate Adaptive Randomization</SPAN></B><B><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-ansi-language: EN-GB"> (</SPAN></B><B><SPAN lang=EN-GB style="FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-ansi-language: EN-GB">Alessandra </SPAN></B><B style="mso-bidi-font-weight: normal"><SPAN lang=EN-GB style="FONT-SIZE: 10pt; FONT-FAMILY: Arial; mso-ansi-language: EN-GB">Giovagnoli, </SPAN></B><SPAN style="FONT-SIZE: 10pt; FONT-FAMILY: Arial">Universitą di Bologna)</SPAN><I style="mso-bidi-font-style: normal"><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold"><o:p></o:p></SPAN></I></P>
<P class=MsoBodyTextIndent3 style="MARGIN: 12pt 0cm 6pt 144.05pt; TEXT-INDENT: -117.1pt; LINE-HEIGHT: 150%; TEXT-ALIGN: center" align=center><B><SPAN style="COLOR: maroon; FONT-FAMILY: Batang">16.00 – 16.30<SPAN style="mso-spacerun: yes"> </SPAN>Coffee Break<o:p></o:p></SPAN></B></P>
<P class=MsoNormal style="MARGIN: 12pt 2.2pt 0pt 144.05pt; TEXT-INDENT: -117.1pt; TEXT-ALIGN: justify"><B><SPAN style="FONT-SIZE: 14pt">16.30 – 17.00</SPAN></B><B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt"><SPAN style="mso-tab-count: 1"> </SPAN></SPAN></B><B><SPAN style="FONT-SIZE: 11pt; FONT-FAMILY: Verdana; mso-bidi-font-size: 12.0pt">A Bayesian adaptive dose-finding trial with count endpoint</SPAN></B><I style="mso-bidi-font-style: normal"><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-weight: bold"><SPAN style="mso-spacerun: yes"> </SPAN></SPAN></I><B style="mso-bidi-font-weight: normal"><SPAN style="FONT-SIZE: 10pt; FONT-FAMILY: Arial">(Luca Pozzi,</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><SPAN style="mso-spacerun: yes"> </SPAN></SPAN></B><SPAN style="FONT-SIZE: 10pt; FONT-FAMILY: Arial">Politecnico di Torino) <B><o:p></o:p></B></SPAN></P>
<P class=MsoNormal style="MARGIN: 12pt 0cm 0pt 144.05pt; TEXT-INDENT: -117.1pt; TEXT-ALIGN: justify"><B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt">17.00 – 17.30<SPAN style="mso-tab-count: 1"> </SPAN></SPAN></B><B><SPAN style="FONT-SIZE: 11pt; FONT-FAMILY: Verdana; mso-bidi-font-size: 12.0pt">The Adjustable Biased Coin Design (ABCD) with covariates</SPAN></B><SPAN style="FONT-SIZE: 11pt; mso-bidi-font-size: 12.0pt"> </SPAN><SPAN style="mso-tab-count: 1"></SPAN><SPAN style="mso-spacerun: yes"> </SPAN><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt">(</SPAN><B style="mso-bidi-font-weight: normal"><SPAN style="FONT-SIZE: 10pt; FONT-FAMILY: Arial">Alessandro Baldi Antognini</SPAN></B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt">, </SPAN><SPAN style="FONT-SIZE: 10pt; FONT-FAMILY: Arial">Universitą di Bologna)<SPAN style="mso-spacerun: yes"> </SPAN></SPAN><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt"><o:p></o:p></SPAN></P>
<P class=MsoNormal style="MARGIN: 12pt 0cm 0pt 144.05pt; TEXT-INDENT: -117.1pt"><B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt">17.30 – 18.00<SPAN style="mso-spacerun: yes"> </SPAN><SPAN style="mso-tab-count: 1"> </SPAN></SPAN></B><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt; mso-bidi-font-weight: bold">Riunione organizzativa dei partecipanti al </SPAN><SPAN style="FONT-SIZE: 14pt; mso-bidi-font-size: 12.0pt">Progetto.<B style="mso-bidi-font-weight: normal"><o:p></o:p></B></SPAN></P>
<P class=MsoBodyTextIndent3 style="MARGIN: 6pt 0cm 0pt 89.4pt; TEXT-INDENT: 16.8pt"><SPAN style="mso-fareast-font-family: Batang"> <o:p></o:p></SPAN></P></FONT></DIV>
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<DIV dir=ltr><FONT face=Arial> Tutti gli interessati sono cordialmente invitati a partecipare</FONT></DIV>
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<DIV><FONT color=#000000><FONT face=Courier>**********************************************************<BR>Prof. Alessandra Giovagnoli <BR>Department of Statistical Sciences<BR>University of Bologna <BR>via Belle Arti 41 <BR>40126 BOLOGNA (Italy) <BR>TELEPHONE: Office +39 051-2098239 <BR><X-TAB> </X-TAB>Fax +39 051-232153<X-TAB> </X-TAB><BR>E-MAIL <A href="mailto:alessandra.giovagnoli@unibo.it" target=_blank>alessandra.giovagnoli@unibo.it</A><BR></FONT><A href="http://www2.stat.unibo.it/giovagnoli/homepage" target=_blank eudora="autourl"><FONT face=Courier>http://www2.stat.unibo.it/giovagnoli/homepage<BR></FONT></A><FONT face=Courier>***********************************************************</FONT></FONT></DIV></DIV></BODY></HTML>