[Forum SIS] Seminar Series in Biostatistics - Unimib

[Rino Bellocco]

Dear colleagues,

next week on March 14 at 2:30 PM we start again our series of seminars 
in Biostatistics, within our Master Program in Biostatistics at the 
University of Milano-Bicocca.

We have the pleasure to host Dr. Erin Gabriel from the Department of 
Medical Epidemiology and Biostatistics, Karolinska Institutet, 
Stockholm, Sweden.

Title://Counterfactuals, Causal Effects and the Evaluation of Surrogates

When: March 14, 2019, 14:30-15:30

Where: Department of Statistics and Quantitative Methods, University of 
Milano-Bicocca,Building U7, 4^th floor, Sala del Consiglio, Room 4064


Abstract:

Valid surrogate endpoints can make clinical trials more efficient, 
allowing for more trials to be conducted and more rapid development of 
effective treatments. One framework for surrogate evaluation is 
principal stratification, wherein the target estimand of interest 
measures vaccine efficacy in subgroups defined by the joint potential 
outcomes of the biomarker endpoint under assignment to the vaccine and 
under assignment to placebo, the unobserved counterfactuals. Unlike 
conditioning on the observed candidate surrogate, this does not induce 
confounding. However, it does cause a systematic missing data problem. 
Several estimation methods and augmented data collection methods have 
been suggested for allowing surrogate evaluation. Once I have introduced 
the potential outcomes framework and the difficulties in evaluating 
candidate surrogates under it, I will present the proposed methods for 
evaluation including both a quick overview of the literature  and a more 
detailed outline of my contributions.

NB:

Any late news, cancellations and other unforeseen events will be 
promptly published on our homepage: *http://biostat.dismeq.unimib.it/**
*

Rino Bellocco and Simona Minotti

-- 
Rino Bellocco, Sc.D.
Department of Statistics and Quantitative Methods,
University of Milano-Bicocca, Milan, Italy

Department of Medical Epidemiology and Biostatistics,
Karolinska Institutet, Stockholm, Sweden

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