[Forum SIS] Seminario Sathyaa SUBRAMANIYAM (RGS & Matematica Applicata)

[Giacomo Aletti]

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scusandomi per invii multipli.
Cordialmente,
Giacomo Aletti

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Nell'ambito dei Reading Group Seminars e del Seminario di Matematica
Applicata, il giorno lunedì 20 Ottobre 2014, alle ore 14.30, nell'Aula
C del Dipartimento di Matematica dell'Universita' degli Studi di
Milano, Via C. Saldini, 50, Milano,

Sathyaa SUBRAMANIYAM
- Department of Brain and Behavioral Science, University of Pavia, Italy
- Consorzio Interuniversitario per le Scienze Fisiche della Materia
(CNISM), Pavia, Italy

terra' una conferenza dal titolo

Detailed computation model for a cerebellar excitatory interneuron


Abstract:

Unipolar Brush Cells (UBCs) have been suggested to play a critical
role in cerebellar functioning, yet the corresponding cellular
mechanisms remain poorly understood. UBCs have recently been reported
to generate, in addition to early-onset glutamate receptor-dependent
synaptic responses, a late-onset response (LOR) composed of a slow
depolarizing ramp followed by a spike burst (Locatelli et al., 2013).
The LOR activates as a consequence of synaptic activity and involves
an intracellular cascade modulating H- and TRP-current gating. In
order to assess the LOR mechanisms, we have developed a UBC
multi-compartmental model (including soma, dendrite, initial segment
and axon) incorporating biologically realistic representations of
ionic currents and a cytoplasmic coupling mechanism regulating TRP and
H channel gating. The model finely reproduced UBC responses to current
injection, including a burst triggered by a low-threshold spike
sustained by CaLVA currents, a persistent discharge sustained by CaHVA
currents, and a rebound burst following hyperpolarization sustained by
H- and CaLVA-currents. Moreover, the model predicted that H- and
TRP-current regulation was necessary and sufficient to generate the
LOR and its dependence on the intensity and duration of mossy fiber
activity. Therefore, the model showed that, using a basic set of ionic
channels, UBCs generate a rich repertoire of bursts, which could
effectively implement tunable delay-lines in the local microcircuit.


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Reading Group Seminars: The Reading Group Seminars (RGS) are organized
within an open community of researchers interested in applying up to
date mathematical modeling and data analysis approaches to the study
of biological systems. The RGS take place at the Math. Department in
Milan (via Saldini). Initiatives and updates are published on the
website: http://rgs.mat.unimi.it/.


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Giacomo Aletti, Associate Professor

ADAMSS Centre (ex MIRIAM)
Advanced  Applied Mathematical  and Statistical Sciences

Department of Mathematics (www.matematica.unimi.it)
Via Saldini, 50
20133 Milano, Italy
Tel: +39-02-503.16158
Fax:+39-02-503.16090
Cell: +39-340-9739142