[Forum SIS] Politecnico di Milano - Seminario F. Chiaromonte

[Laura Sangalli]

Si avvisa che in data 19-10-2012, alle ore 14:30 precise,
presso Aula Seminari F. Saleri VI Piano MOX - Dipartimento di 
Matematica, Politecnico di Milano,
nell'ambito delle iniziative MOX si svolgerà il seguente seminario:


Speaker: Francesca Chiaromonte, The Pennsylvania State University

Title: Statistical characterizations of genome dynamics

Abstract: Recent studies of sequenced genomes have shown that the rates 
of different types of mutations tend to vary and co-vary along the nuclear
DNA. In order to provide a statistical characterization of this 
variation structure and of its association with features of the local 
genomic
landscape, we have used a number of multivariate techniques on data from 
primate alignments (these include regression, linear and non-linear
Principal Components, linear and non-linear Canonical Correlations). 
Most recently we have used multivariate Hidden Markov Models to identify
distinct mutational patterns and segment the human genome accordingly. 
Our results provide crucial insights into genome dynamics, and the 
mutagenic
role of various molecular mechanisms such as replication, recombination, 
repair and local chromatin environment. Moreover, we identify regions with
distinct mutational signatures whose locations, lengths and landscapes 
are evolutionarily meaningful.
This is joint work with Guru Ananda, Prabhani Kuruppummullage Don and 
Kateryna Makova of The Pennsylvania State University.



Tutti gli interessati sono invitati a partecipare.


-- 
Laura Maria Sangalli
MOX - Dipartimento di Matematica
Politecnico di Milano
Piazza Leonardo da Vinci 32
20133 Milano - Italy
tel: +39 02 2399 4554
fax: +39 02 2399 4568
email: laura.sangalli at polimi.it
url: http://mox.polimi.it/~sangalli