[Forum SIS] Bocconi DEC Seminar: Peter Green - May 20th

[Anna Simoni]

Dear colleagues, 

The Department of Decision Sciences (DEC) of Bocconi University is pleased to invite you to the seminar: 

================================================================== 

DEC Seminar 
Università Bocconi, 
Room 3-E4-SR03 
Via Roentgen 1 - 3rd floor 
Time: 12:30pm 

The DEC seminar schedule is available at http://www.unibocconi.eu/statseminar 

Thursday, May 20th 

Peter Green 
(Department of Mathematics, University of Bristol) 

"Colouring and breaking sticks, pairwise coincidence losses, and clustering expression profiles " 

Abstract: 

We consider methodology for Bayesian model-based clustering of gene 
expression profiles, that is, measurements of expression levels of a 
large number of genes, typically from microarray assays, across a number 
of different experimental conditions and/or biological subjects. We 
follow a familiar approach using Dirichlet-process-based models to 
cluster the genes implicitly, but depart from standard practice in 
several ways. First, we incorporate regression on covariate information 
at the condition/subject level by modelling regression coefficients, not 
the expectations of the data directly. More importantly, we replace the 
Dirichlet process by one of a richer family of models, generated from a 
stick-colouring-and-breaking construction, under which cluster 
identities are not exchangeable: this allows modelling a 'background' 
cluster, for example. Finally, we follow a formal decision-theoretic 
approach to point estimation of the clustering, using a pairwise 
coincidence loss function. This is joint work with John Lau. 
============================================================================== 

Sincerely, 
Anna Simoni ----------------------------- 
Anna Simoni 

Assistant Professor 
Department of Decision Sciences 
Università Bocconi 
via Roentgen, 1 
20136 Milano - Italy 

Email:anna.simoni a unibocconi.it 
Webpage: http://faculty.unibocconi.eu/annasimoni/ 


---
Il messaggio che segue e' inserito automaticamente dal server di posta
dell'Universita' Bocconi.

Il 5 per mille per gli studenti meritevoli della Bocconi.
E' un atto volontario, non costa nulla e non sostituisce l'8 per mille.
Scegli Bocconi: codice fiscale 80024610158.

Please note that the above message is addressed only to individuals
filing Italian income tax returns.
---

-------------- parte successiva --------------
Un allegato HTML è stato rimosso...
URL: <http://www.stat.unipg.it/pipermail/sis/attachments/20100512/b3a64f48/attachment.html>