[Forum SIS] Avviso di seminario - Dr. John Taffe, Monash University, Melbourne, Australia

[Maria Giovanna Ranalli]

Venerdi 16 Ottobre, ore 12
Dipartimento di Economia, Finanza e Statistica, Aula 101
Università degli Studi di Perugia

.: Dr John Taffe, Monash University, Melbourne Australia :.
.: Random effects regression with menstrual markers of the menopausal  
transition   :.

Aim
Verify the classification into ‘early’ or ‘late’ of certain elements  
of patterns of sequences of menstrual cycle lengths defined as markers  
of entry to stages of the menopausal transition.  The transition is  
defined as a time of increasing variability in cycle length leading up  
to the final menstrual period.

Method

Random effects regression of cycle length sequences on age during  
person-dependent time intervals beginning at age 35 years and ending  
at the age at which the marker event occurs to each woman, using data  
from a landmark study (the TREMIN data).

Results

With cycle-dependent events previously designated as markers of entry  
to the ‘early’ stage of the transition as age-endpoints, age-slope  
estimates are negative (a continuation of the pattern established  
during the reproductive years).  With ‘late’ stage markers as  
endpoints, increasing cycle length variability ensures age-slope  
estimates are positive.

Conclusion

A simple but powerful statistical technique applied in a slightly  
unconventional way confirms the classification already agreed by the  
ReSTAGE Collaboration, an international research group.




Cordiali saluti

M. Giovanna Ranalli

~ Dipartimento di Economia, Finanza e Statistica
~ Sezione di Statistica
~ Via Pascoli
~ 06123 Perugia - Italy

~ Tel +39 075 5855939
~ Fax +39 075 5855950
~ url: www.stat.unipg.it/~giovanna

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